A girl flees her house in fear and It Follows drives to the beach where she calls her father. By morning, she has been brutally murdered.
Jay, a college It Follows student, goes to see a film with her boyfriend Hugh. While they are waiting in line, Hugh starts talking about how envious he is of young children and how they have innocent, carefree lives. When they are inside the theater, Hugh spots a young woman at the entrance. He points her out to Jay, but she, however, cannot see her. Suddenly, Hugh starts getting afraid and demands to Jay that they leave the theater. On another date, Hugh and Jay have sex in his car, before he It Follow incapacitates her with chloroform. She wakes up tied to a wheelchair and Hugh explains that he has passed her a curse through It Follow sex. He informs her that an entity which can only be seen by those with the curse will pursue Jay at walking pace. If it catches her, it will kill her and then go after the person who passed it to her. A naked woman emerges from the nearby woods and approaches them, and Hugh drops Jay off at home.
The next day at school, Jay encounters an old woman in a night gown slowly approaching her and rushes to where her sister, Kelly, works. Jay’s sister and her friends Yara and Paul, who has an obvious crush on Jay, decide to help and spend the night in the same house. Paul investigates a smashed kitchen It Follow window but sees no one; Jay sees a half-naked and bloodied woman walking toward her. Jay runs upstairs to the others, who cannot see the entity. When a tall man with gouged-out eyes enters the bedroom, Jay flees the house and rides a bike to a nearby playground, where her friends regroup It Follows.